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Since it is a neuromodulator, it blocks the nerve signals to your muscles temporarily

Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized

This is really the whole argument for working with a supplier that provides a batch-specific Certificate of Analysis rather than taking purity claims on faith

For more on keeping vitamin levels up, even if youre on meds like metformin, check out Mayo Clinics guide to vitamin B12